Introduction
The fascinating intersection of mechanobiology and hydraulics has been attracting significant attention in recent years. Researchers have been uncovering how mechanical processes direct morphogenesis across various scales, including the role of hydraulics in biology. I recently attended the Cell & Tissue Hydraulics Mini-Symposium, held online, which brought together experts in the field to discuss their latest research findings and pave the way for future collaborations. Despite the limited interaction due to the online format, the symposium provided an incredible opportunity to learn about cutting-edge developments in the field. In this blog post, I will provide a list of essential papers to check out.
Key Papers to Check Out
The following is a list of essential papers presented at the mini-symposium that I highly recommend checking out to gain a deeper understanding of the role of hydraulics in biology:
- Ethology of morphogenesis reveals the design principles of cnidarian size and shape development. https://doi.org/10.1101/2021.08.19.456976
- Hydraulic control of mammalian embryo size and cell fate. https://doi.org/10.1038/s41586-019-1309-x
- Size control of the inner ear via hydraulic feedback. https://doi.org/10.7554/eLife.39596
- Organ size control via hydraulically gated oscillations. https://doi.org/10.1242/dev.153056
- Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis. https://doi.org/10.1101/2020.09.28.316042
- Fusion of airways during avian lung development constitutes a novel mechanism for the formation of continuous lumena in multicellular epithelia. https://doi.org/10.1002/dvdy.215
- A mechano-osmotic feedback couples cell volume to the rate of cell deformation. https://doi.org/10.1101/2021.06.08.447538
- Quantitative coupling of cell volume and membrane tension during osmotic shocks. https://doi.org/10.1101/2021.01.22.427801
- Inferring cell junction tension and pressure from cell geometry. https://doi.org/10.1242/dev.192773
- Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation. https://doi.org/10.1073/pnas.2022422118
- Volumetric compression induces intracellular crowding to control intestinal organoid growth via Wnt/β-catenin signaling. https://doi.org/10.1016/j.stem.2020.09.012
- Trans-epithelial fluid pumping performance of renal epithelial cells and mechanics of cystic expansion. https://assets.researchsquare.com/files/rs-524708/v1_covered.pdf?c=1631868288
- Extracellular Hydraulic Resistance Enhances Cell Migration. https://doi.org/10.21203/rs.3.rs-108471/v1
- Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area. https://doi.org/10.1126/sciadv.aaw7243
- Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size.https://doi.org/10.1038/s41467-020-19308-5
- Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo. https://doi.org/10.1038/ncb3320
Conclusion
The Cell & Tissue Hydraulics Mini-Symposium was an enlightening event that offered a unique glimpse into the current state of research in the fields of mechanobiology and hydraulics. Despite the limitations of the online format, the symposium provided a valuable opportunity to learn about new advancements and techniques in the field. By exploring these essential papers, you too can gain a deeper understanding of the role of hydraulics in biology and appreciate the significance of this fascinating area of research.