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Ph.D. in Applied Mathematics

Universitat Politècnica de Catalunya, Barcelona, Spain

• Mechanics of epithelial layers subjected to controlled pressure and tension
• Supervised by
  • Prof. Xavier Trepat
  • Prof. Marino Arroyo

M.E. in Mechanical Engineering

Indian Institute of Science, Bengaluru, India

• Design and fabrication of miniature shear device for cell mechanics
• Supervised by
  • Prof. Namrata Gundiah

B.Tech. in Mechanical Engineering

Visvesvaraya National Institute of Technology, Nagpur, India

• Design and Fabrication of a Hirda (Terminalia chebula) Cracking Machine
• Supervised by
  • Prof. Pramod Padole

• Pullarkat, P., Vishwakarma, R., Gundiah, N., and Chahare, N. R., A microscope mountable fluid shear device. Indian patent, IN201641029893A, pg 275/677 Published 2018-03-09.

• Andreu, I. + , Granero-Moya, I. + , Chahare, N. R., Clein, K., Jordàn, M. M., Beedle, A. E., … & Roca-Cusachs, P. (2022). Mechanical force application to the nucleus regulates nucleocytoplasmic transport. Nature Cell Biology

• Andreu, I. + , Falcones, B. + , Hurst, S., Chahare, N., Quiroga, X., Le Roux, A. L., … & Roca-Cusachs, P. (2021). The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening. Nature communications, 12(1), 1-12.
• Chatterjee, A., Chahare, N. R., Kondaiah, P., & Gundiah, N. (2021). Role of Fiber Orientations in the Mechanics of Bioinspired Fiber-Reinforced Elastomers. Soft Robotics, 8(6), 640-650.

• Kundanati, L., Chahare, N. R., Jaddivada, S., Karkisaval, A. G., Sridhar, R., Pugno, N. M., & Gundiah, N. (2020). Cutting mechanics of wood by beetle larval mandibles. Journal of the Mechanical Behavior of Biomedical Materials, 112, 104027.

Ph.D. student

Institute for Bioengineering of Catalonia, and UPC

• Mechanics of epithelial layers subjected to controlled pressure and tension
  • Designed a microfluidic chip to control epithelial shapes and pressure.
  • Performed rheological study with inflated epithelial monolayers to understand actomyosin cortex remodelling.
  • Discovered a new method to generate epithelial folds via mechanical phenomena of buckling.
• Computational tool for analysing nuclear to cytoplasmic transport
  • Working in collaboration with Prof. Pere Roca-Cusachs and Ion Andreu, developed a MATLAB script to calculate import and export rate of mechanosensitive protien.
  • Developed a fitting algorithm to elucidate protein mobility with Fluorescence recovery after photobleaching (FRAP).
  • Utilized an elegant system of differential equations to analyse data from Fluorescence Loss in Photobleaching (FLIP).
• Analysis of force loading rates associated with cell mechanosensing
  • Working in collaboration with Prof. Pere Roca-Cusachs and Victor Gonzalez-Tarrago, developed a MATLAB script for analysing atomic force microscopy data from JPK software raw data.
  • Analysed timeseries data from AFM experiments to determine detachment force.
  • Analysed optical tweezer experiments by fiting curves piecewise linearly to calculate stiffness of the cells.

Project Associate

Biomechanics Lab, Indian Institute of Science

• Developing constitutive model of Fiber Reinforced Elastomers (FRE)
  • Computed stresses and strains from uniaxial and biaxial stretching experiments of Polydimethylsiloxane Fibre Reinforced Elastomer.
  • Modeled experimental results using hyperelastic constitutive equation.
  • Performed constrained optimization using custom built MATLAB program for fitting the experimental results.

Masters student

Mechanical Engineering, Indian Institute of Science

• Design and fabrication of miniature shear device for cell mechanics
  • Designed a cost effective system capable of applying uniform shear on culture cells along with real time visualization using fluorescence microscopy.
  • Implemented trajectory generation filter based control system in the shear device electronics using MATLAB and Arduino programming.
  • Calibrated the device using fluorescence microscopy and traction force microscopy to test for uniform shear flow conditions.
• Finite element analysis of coffee white stem borer (CWSB) mandible
  • Created geometry of insect mandible from tomography data using image processing and CAD modeling.
  • Stress and displacement distribution on mandible during wood boring were computed using commercial FEA package, ABAQUS.
  • Stresses on the mandible were used to examine the morphological adaptations that provide distinct mechanical advantages to the insect for cutting purposes.

• Chahare, N. R., Ouzeri, A., Golde, T., Wilson, T., Roca-cusachs, P., Arroyo, M., and Trepat, X. “ Harnessing active viscoelasticity for synthetic epithelial morphogenesis.” German Physics Society, Dresden, Germany. March 26-31, 2023

• Chahare, N. R., Ouzeri, A., Golde, T., Wilson, T. Arroyo, M., and Trepat, X. “Shaping epithelia through buckling in pressure-controlled tissue.” World congress of biomechanics, Taipei, Taiwan. July 10-14, 2022
• Chahare, N. R., Ouzeri, A., Golde, T., Wilson, T. Arroyo, M., and Trepat, X. “Synthetic epithelial morphogenesis through controlled stretching and buckling.” EMBL-IBEC Conference, Engineering multicellular systems, Barcelona, Spain. June 08-10, 2022
• Chahare, N. R., Ouzeri, A., Golde, T., Wilson, T. Arroyo, M., and Trepat, X. “Synthetic epithelial morphogenesis through controlled stretching and buckling.” EMBO-EMBL Symposium, Mechanobiology in development and disease, Heidelberg, Germany. May 15–18, 2022

• Chatterjee, A., Chahare, N. R., Kulkarni, A., Kondaiah, P., and Gundiah, N. “Design of adynamic cell stretcher to quantify responses of fibroblasts to cyclic stretching and TGF-β.”5th International Conference on Computational and Mathematical Biomedical Engineering,Pittsburgh, Pennsylvania, USA. April 10–12, 2017

• Satone, V., Chahare, N. R., and Padole, P. “Design of pedal operated behda crackingmachine using flywheel motor.” Association for Machines and Mechanisms’ IndustrialProblems on Machines and Mechanisms (IPRoMM), Nagpur, India. Dec 22–23, 2016
• Abhijith, K. G., Chahare, N. R., Kundanati, L., and Gundiah, N. “Mechanics of the Cuticleof Wood Boring Insects.” Structural Integrity Conference and Exhibition (SICE), Bengaluru,India. July 4–6, 2016

• Mentored Gavin McQuarrie, student from University of Glasgow, jointly with Anabel-lise Le Roux to calibrate and develop stretch system.
• Undertook Alexandre Garcia-Duran as summer student in University of Barcelona Intership project of characterizing stiffness of PDMS and developing a Microfluidic device for stretching cells/tissues.

• Trained two high school students in a project related to 3D epithelia at Institute for Bioengineering of Catalonia with Treball de Recerca program.

• Won the best poster prize at 15th IBEC SYMPOSIUM on Bioengineering for Active Ageing, Barcelona, Spain, 2022.

• International travel grant for attending winter school on Quantitative Systems Biology at International Centre for Theoretical Sciences (ICTS), Bengaluru, India 2019.

• Received second prize for Best paper presentation in Association for Machines and Mechanisms’ Industrial Problems on Machines and Mechanisms (IPRoMM), Nagpur, India

• Awarded scholarship by Ministry of Human resource and development, India for M.E. 2014-16.
• All India Rank 362 (99.8 percentile) out of 185,578 in Graduate Aptitude Test in Engineering

• Bagged 22nd position in national level presentation competition for future transportation solution, TATA MOTORS’ MIND ROVER.